A moderate drug interaction exists between Benadryl and Methamphetamine. View detailed information regarding this drug interaction. Several studies have demonstrated that first generation antihistamines potentiate methamphetamine-induced psychomotor activation and two possible mechanisms … 1978 Diphenhydramine can also be used for its sedative and antiemetic effects. It acts as an antagonist for the histamine 1 (H1) receptor, reversing … La diphénhydramine (DHM) est une substance chimique utilisée comme antihistaminique H 1 de première génération, de la famille pharmacologique des … While helpful when used correctly, long-term abuse can lead to significant health risks and addiction. Understanding Benadryl (Diphenhydramine). The lethal dose of Benadryl depends on many factors but has been estimated to be 20 to 40 mg/kg for adults. Learn more now. FDA warns against taking higher than recommended doses of over-the-counter Benadryl, which can lead to serious problems and death. Meth · Opioids · Prescription Drugs … So between 6 to 12 hours after taking Benadryl, half the drug will be eliminated from the body.