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Find patient medical information for Selegiline (Eldepryl) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Selegiline, also known as L-deprenyl and sold under the brand names Eldepryl, Zelapar, and Emsam among others, is a medication which is used in the treatment of Parkinson's disease and major depressive disorder. [4][6][8][3] It has also been studied and used off-label for a variety of other indications, but has not been formally approved for … Eldepryl (selegiline) is used together with other medicines to treat symptoms of Parkinson's disease. Includes Eldepryl side effects, interactions and indications. The patient benefits of Eldepryl are substantial – Daily L-dopa intake can be immediately cut by 20% in most cases,1 reducing unwanted side effects and extending the useful life of L-dopa. Eldepryl significantly reduces akinesia, and has been shown to smooth out "on-off" effects. 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