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Xifaxan (rifaximin) is a prescription antibiotic used to treat irritable bowel syndrome with diarrhea (IBS-D), traveler's diarrhea caused by certain strains of E. coli, and to reduce the risk of recurrent hepatic encephalopathy in adults with liver disease. Shop Best Buy for electronics, computers, appliances, cell phones, video games & more new tech. Store pickup & free 2-day shipping on thousands of items. Get the best price on Xifaxan at pharmacies near you with SingleCare. Save up to 80% with our Xifaxan coupons – with or without insurance! Get the facts on cost and Xifaxan, how the generic compares with the brand name, what financial assistance may be available, and more. Compare Xifaxan 550 mg prices from verified online pharmacies or local U.S. pharmacies. Free coupons for Xifaxan. Discounts up to 80% off the retail price. Rifaximin (Xifaxan) treats diarrhea caused by traveling or irritable bowel syndrome. It can also prevent hepatic encephalopathy. 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